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Breakthrough FDA Approval: Zegfrovy (Sunvozertinib) Targets Rare Lung Cancer

 Administration granted accelerated approval to Zegfrovy ( sunvozertinib ) for adults with locally advanced or metastatic non‑small cell lung cancer (NSCLC) harboring EGFR exon 20 insertion mutations , following progression on platinum‑based chemotherapy.  Clinical Trial Highlights Overall response rate (ORR): 46% (95% CI, 35–57%) as per the phase 1/2 WU‑KONG1B study involving 85 patients. Duration of response (DoR): Median 11.1 months (95% CI, 8.2–not reached). Manageable safety profile: Includes gastrointestinal effects, dermatologic and ocular toxicity, pneumonitis risks.  Companion Diagnostic Innovation On July 7, 2025, FDA also approved the Oncomine™ Dx Express Test (Ion Torrent Genexus Dx) to rapidly detect EGFR exon 20 insertions, enabling timely precision oncology decisions.  Global Context & Future Developments Sunvozertinib had previously received conditional approval in China (WU‑KONG6 study, ...
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Hidden Dangers in Food Packaging: Toxic Chemicals Linked to Cancer and Hormone Disruption

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  Toxic chemicals from food packaging can migrate into your meals—posing risks of cancer, hormone disruption, and reproductive harm./ Pexels  A  landmark study, published in the Journal of Exposure Science & Environmental Epidemiology , has revealed alarming findings: more than 3,600 food contact chemicals (FCCs)—roughly 25% of all known FCCs—have been detected in human biomonitoring samples. This first-of-its-kind evidence links everyday food packaging materials with widespread chemical exposure, igniting fresh calls for stronger regulation and increased consumer awareness.  Scientific Findings Dr. Birgit Geueke and colleagues conducted an extensive review of over 14,000 FCCs commonly found in packaging, storage, processing, and kitchen utensils. By cross-referencing five biomonitoring programs (including blood, urine, breast milk) and three exposome/metabolome databases, they confirmed that 3,601 different FCCs are present in humans . Notably, about 8...
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Sweetened Treats & Precocious Puberty: What New Science Reveals

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Frequent consumption of sweetened foods like ice cream may disrupt hormonal balance and trigger early puberty in genetically susceptible children./Pexels  A new large-scale study conducted by researchers at Taipei Medical University and Wan Fang Hospital in Taiwan and presented at the Endocrine Society’s 2025 annual meeting indicates a strong link between sweetener consumption and central precocious puberty (CPP) in children.  What Did the Study Find? The cohort included 1,407 teenagers , of whom 481 were diagnosed with CPP—defined as puberty before age 8 in girls or age 9 in boys . Researchers analyzed dietary intake using validated food questionnaires and urinary biomarkers, while genetic predisposition was assessed via polygenic risk scores based on 19 CPP-related genes . Consumption of aspartame, sucralose, glycyrrhizin (from licorice root), and added sugars significantly correlated with CPP risk—and the ...
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Scientists Raise Alarm: Erythritol Sweetener May Damage Brain Cells & Boost Stroke Risk

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New research suggests erythritol may impair brain blood vessel function and increase stroke risk. / Pexels   What Is Erythritol? Erythritol is a sugar alcohol approved by the FDA in 2001. It offers ~60–80% of sugar's sweetness with minimal calories and negligible impact on blood sugar  , making it a common ingredient in low-carb, keto, and diabetic-friendly products 1.  New Laboratory Findings A recent Journal of Applied Physiology study by Berry et al. (June 16, 2025) investigated erythritol’s effects on human brain microvascular endothelial cells. Results showed: ↑ Reactive oxygen species (ROS) and oxidative stress (+75%), plus increased antioxidant enzyme expression (SOD‑1 +45%, catalase +25%) 2; ↓ Nitric oxide bioavailability (~20% drop) and altered eNOS enzyme regulation 3; ↑ Release of vasoconstrictive endothelin‑1 (ET‑1) 4; ↓ Thrombin-stimulated t‑PA (clot‑dissolving protein...
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How Pregnancy-Related Hypertension Impacts Breastfeeding: New Yale Insights

 A recent study from Yale University, featured in JAMA Network Open , explores how hypertensive disorders during pregnancy are linked to lower breastfeeding initiation and shorter duration. The Scope of Hypertensive Disorders in Pregnancy (HDP) Hypertensive disorders of pregnancy (HDP)—which include chronic or gestational hypertension, preeclampsia, and eclampsia—pose serious risks for mothers and babies in the U.S. From 2017 to 2019, HDP affected approximately 16% of pregnancies, disproportionately impacting non‑Hispanic Black and American Indian/Alaska Native women . Beyond immediate complications like preterm birth, HDP also raises long-term risks of cardiovascular disease , kidney failure, and stroke . Key Findings: Hypertension Undermines Breastfeeding Success Yale researchers analyzed national data from the CDC Pregnancy Risk Assessment Monitoring System (PRAMS), covering live births be...
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Drink Up: How 3 Cups of Coffee Daily Can Boost Your Heart Health

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  Moderate coffee consumption—around 3 cups a day—was linked to a 48.1% lower risk of cardiometabolic multimorbidity / Pexels  Great news for coffee lovers: drinking one to three cups of coffee or tea daily may significantly improve heart and metabolic health. A new study links moderate caffeine intake to a substantially lower risk of developing cardiometabolic multimorbidity —meaning multiple conditions like type 2 diabetes, coronary heart disease, and stroke.  What the Latest Research Shows A  prospective cohort study, led by Dr. Chaofu Ke of Soochow University (China) and published in the Journal of Clinical Endocrinology & Metabolism , analyzed data from the UK Biobank involving over 360,000 healthy adults aged 37–73 . Participants with no prior cardiometabolic disease were assessed over 11–12 years. Consumption levels categorized as:   – Low (   – Moderate (200–300 mg caffeine/d...
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Osteoporosis Treatment After Fracture Benefits Patients Over 80

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Osteoporosis is a progressive bone disease marked by diminished bone density and higher fracture risk. Recent data presented at ENDO 2025 highlight the importance of initiating treatment after a fragility fracture in patients over 80 years old. New Scientific Evidence A large observational study from the Cleveland Clinic, using the TriNetX database, tracked 88,676 patients aged 80+ who suffered fragility fractures. Half received osteoporosis medications—bisphosphonates, denosumab, raloxifene, or teriparatide—while the other half did not. After five years, those treated had significantly lower rates of hospitalization and all-cause mortality . Key Findings Hospitalization reduced (OR ≈ 0.81; 95% CI 0.79–0.84) All‑cause mortality reduced (OR ≈ 0.85; 95% CI 0.83–0.88) 2 Adjusted for comorbidities: hypertension, diabetes , heart disease, COPD, CKD, vitamin D deficiency, etc.  Why This Matters The...
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